Since antiquity, many prominent thinkers of the world, from Plato to Tagore and from Newton to Einstein, have attempted to unveil the nature of reality. But reality seems always deeper than our feeble minds can comprehend. Can a combined effort of science and spirituality, the two most dominant forces of humanity, help to delve deeper into the reality? This unique dialogue between Dr. T.D. Singh and Sir Roger Penrose; like the well known East-West dialogue between Tagore and Einstein, is a sincere attempt to seek some possible answers to the question of reality. Reflecting on a wide range of topics from consciousness to cosmology and from scientific mystery to mathematical beauty, this dialogue will provide readers with useful insights in their quest for the ultimate reality.